GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 size:10mg solid InChi: InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7

InChi: InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7

Solubility: DMSO up to 15 mM

particularly for the p53R175 mutant

(2011) Chem Biol

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 size:10mg solid InChi: InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7GSK2879552 dihydrochloride, CAS No. 1902123 72 1, is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO A B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions