SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid RVX-208 functions by removing atherosclerotic

RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT)

and effecting cellular metabolism

InChiKey: RWKUVRQLFRJTTR-UHFFFAOYSA-N

PD153035 HCl (ZM 252868

PFI-3 is a very useful chemical probe to study the key chromatin remodeling and transcription control

SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid RVX-208 functions by removing atheroscleroticSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low