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Epub 2011 Feb 1
BT474 and SKBR3 cell lines
GSK-2256098
At the molecular level
Forskolin activation of adenylate cyclase in vivo stimulates nerve regeneration
AP 1903 - CAS# 195514-63-7 size:2mg solid Epub 2011 Feb 1AP 1903, CAS No. 195514 63 7, also known as Rimiducid, is a lipid permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild type FKBP12 with 1000 fold lower affinity. This agent is used to homodimerize the Fv containing drug binding domains of genetically engineered receptors such as the iCD40
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