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Smiles: COC1=CC(=CC=C1NC1=NC(NC)=C(Cl)C=N1)C(=O)N1CCOCC1
It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members
2006 Jan-Feb
MMAF inhibits anaplastic large cell lymphoma Karpas 299
correct frataxin deficiency and increases histone acetylation in the brain and heart of KIKI mice without acute toxicity signs
I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 Catalog No.:M60154-10S Smiles: COC1=CC(=CC=C1NC1=NC(NC)=C(Cl)C=N1)C(=O)N1CCOCC1I BET762 (GSK525762), CAS No. 1260907 17 2, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain containing proteins. In vivo studies using I BET762 have demonstrated efficacy in a range of oncology and
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