![PF-3450074 60276 Chemical Name: 5-[2-(dimethylamino)ethoxy]-N-{3-[4-(hydroxycarbamoyl)phenyl]prop-2-yn-1-yl}-1H-indole-2-carboxamide](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M32054_1636090811.gif?v=1636090812)
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Chemical Name: 5-[2-(dimethylamino)ethoxy]-N-{3-[4-(hydroxycarbamoyl)phenyl]prop-2-yn-1-yl}-1H-indole-2-carboxamide
it against Plasmodium falciparum and E
Solubility: DMSO : ≥ 25 mg/mL (64
3-dioxygenase (IDO1) inhibitor with IC50 ~10 nM It displays high selectivity over other related enzymes such as IDO2 or tryptophan 2
) alleviates D-GalN induced hepatotoxicity in mice
PF-3450074 60276 Chemical Name: 5-[2-(dimethylamino)ethoxy]-N-{3-[4-(hydroxycarbamoyl)phenyl]prop-2-yn-1-yl}-1H-indole-2-carboxamidePF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors
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