E1R isocyanurate InChi: InChI=1S/C9H13N5O6/c10-7-4(14(18)19)8(12-2-11-7)13-9-6(17)5(16)3(1-15)20-9/h2-3

InChi: InChI=1S/C9H13N5O6/c10-7-4(14(18)19)8(12-2-11-7)13-9-6(17)5(16)3(1-15)20-9/h2-3

(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs

2(9):938-42

The X-ray structure of PLpro in complex with GRL0617 indicates that the compound has a unique mode of inhibition whereby it binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site

The IC(50) of 1

E1R isocyanurate InChi: InChI=1S/C9H13N5O6/c10-7-4(14(18)19)8(12-2-11-7)13-9-6(17)5(16)3(1-15)20-9/h2-3E1R is a positive allosteric modulator of sigma 1 receptors (Sig1R PAM) with cognition enhancing activity. Product information CAS Number: 1301211 78 8 Molecular Weight: 232. 28 Formula: C13H16N2O2 Chemical Name: 2 [(2S,3R) 2 methyl 5 oxo 3 phenylpyrrolidin 1 yl]acetamide Smiles: C[C@H]1[C@H](CC(=O)N1CC(N)=O)C1C=CC=CC=1 InChiKey: ZTGRWYMPQCQTHD ONGXEEELSA N InChi: InChI=1S C13H16N2O2 c1 9 11(10 5 3 2 4 6 10)7 13(17)15(9)8 12(14)16 h2 6,9,11H,7