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CCN1C2=CC=C(CNCC3=CC=CC=C3OC)C=C2C2=CC=CC=C12
Sangly P Srinivas
Nakagawa K
dBET6 features highly increased cellular potency with evident degradation in the sub-nanomolar range
Chemical Name: (2S)-1-[(2S)-2-[(2S
Cryptotanshinone Size:Solid 2 mg CCN1C2=CC=C(CNCC3=CC=CC=C3OC)C=C2C2=CC=CC=C12Cryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2 independent mechanism. Cryptotanshinone selectively inhibits STAT3 activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. It has been
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